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Chemical & Biomolecular Engineering


Srivatsan Kidambi
Assistant Professor
Srivatsan Kidambi

Contact

Srivatsan Kidambi

Education

  • Postdoctoral Research Fellow, Harvard Medical School and Massachusetts General Hospital, 2009
  • Ph.D., Chemical Engineering and Materials Science, Michigan State University, 2007
  • M.S., Chemistry, Michigan State University, 2002
  • B.S., Chemistry, University of Madras, India, 1999

Courses Taught

  • CHME 114 Introduction to Chemical Engineering II
  • CHME 202 Mass and Energy Balances
  • CHME 496/896 Micro/Nano Systems in Engineering & Life Sciences

UNL Digital Commons

Read full text versions of our faculty's past and current papers, competitive grant applications and patents online in the UNL Digital Commons.

Curriculum Vitae

Personal Description


Dr. Kidambi’s research program focuses on the development of novel nanostructured materials with highly controlled architectures and chemistries for tissue engineering and drug delivery applications. The materials developed through this research will address some of the key challenges of regenerative medicine and drug delivery. His research group has a strong emphasis on multidisciplinary collaborations with chemists, biologists, material scientists and neuroscientists. The research projects will exploit classical engineering principles to increase understanding of the ways that cells receive information from materials, and what happens to cell function over time when assembled within three-dimensional microenvironments. The goal of his research program is to design novel surfaces for understanding the underlying biology of neurodegenerative diseases such as Alzheimer’s and engineer novel therapeutic approaches. Prior to joining UNL, he was a postdoctoral fellow in Harvard Medical School and worked in Hitachi Chemical Research Center as a research engineer. His Ph.D. is in Chemical Engineering and M.S. is in Chemistry from the Michigan State University, East Lansing, and his B.S is in Chemistry from the University of Madras, India.

Education


  • 2009 Postdoctoral Research Fellow, Harvard Medical School and Massachusetts General Hospital
  • 2007 Ph.D., Chemical Engineering and Materials Science, Michigan State University
  • 2002 M.S.Chemistry, Michigan State University
  • 1999 B.S.Chemistry, University of Madras, India

Research Interests


  • Neural and Stem Cell Tissue Engineering: To develop surfaces to (i) engineer patterned co-cultures of neurons and other cell types (ii) differentiate adult neural stem cells (NSCs) using a combination of physical, chemical and biological cues at the cellular level.
  • Nano-scale Drug Delivery System for Gene Therapy: To develop novel drug and vaccine delivery systems, which provide spatial and temporal regulation of drug signaling or stem cell growth and differentiation from the targets identified above.
  • Novel Thin Films for Sensor Applications: To develop microarrays of biomaterials for high throughput screening as biosensors.

Recent Publications


  • “Aptamer Incorporated Polyelectrolyte Multilayer Films Targeting Influenza Virus’s Hemagglutinin Binding Region” Srivatsan Kidambi, Ilsoon Lee, Christina Chan., (in preparation)
  • “Topography Mediated Regulation of HER-2 Expression in Breast Cancer Cells” Amita Daverey, Austin Mytty, Srivatsan Kidambi *, submitted (NanoLife)
  • “Propofol induces MAPK/ERK cascade dependant expression of c-Fos and Egr-1 in rat hippocampal slices” Srivatsan Kidambi*, Joel Yarmush, Yevgeny Berdichevsky, Sangeetha Kamath, Wayne Fong, Joseph SchianodiCola, BMC Research Notes, 17(3), 201-206, 2010
  • “Oxygen-Mediated Enhancement of Metabolism, Functional Polarization, Gene Expression an Drug Clearance in Cocultures of Primary Hepatocytes” Srivatsan Kidambi, Eric Novik, Ruby Yarmush, Piyun Chao, Martin Yarmush, Yaakov Nahmias, Proceedings of the National Academy of Science, 106(37), 15714-9, 2009.
  • “Propofol induces a Dose-Dependent Alteration in the Expression of c-Fos and Egr-1 in Neuronal Cells” Srivatsan Kidambi*, Joel Yarmush, Wayne Fong, Sangeetha Kamath, Joseph SchianodiCola, Yaakov Nahmias, NeuroReport, 20(7), 657-662, 2009.
  • “Tunable Resistive m-dPEG Acid Patterns on Polyelectrolyte Multilayers at Physiological Conditions:  Template for Directed Deposition of Biomacromolecules” Srivatsan Kidambi, Christina Chan*, Ilsoon Lee*., Langmuir,24(1),224-30, 2008.
  • “Patterned Co-culture of Neurons and Astrocytes on Polyelectrolyte Multilayer Films for Studying Astrocyte Mediated Oxidative Stress in Neurons” Srivatsan Kidambi, Ilsoon Lee, Christina Chan. Advanced Functional Materials, 18, 294-301, 2008.
  • “Selective Adhesion of Primary Hepatocytes on Polyelectrolyte Multilayers: Template for Patterned Cell Co-culture” Srivatsan Kidambi, Lufang Sheng, Mehmet Toner, Martin Yarmush, Ilsoon Lee, Christina Chan. Macromolecular Biosciences, 7(3), 344-53, 2007.
  • “Cell Adhesion on Polyelectrolyte Multilayer coated PDMS Surfaces with Varying Topographies” Srivatsan Kidambi, Natasha Udpa, Stacey Schroeder, Ilsoon Lee, Christina Chan. Tissue Engineering, 13 (8), 2105-2117, 2007.
  • “Controlling Primary Hepatocyte Adhesion and Spreading on Protein Free Polyelectrolyte Multilayer Films” Srivatsan Kidambi, Ilsoon Lee, Christina Chan. Journal of the American Chemical Society, 126 (50), 16286 -16287, 2004.
  • “Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Templates” Srivatsan Kidambi, Christina Chan, Ilsoon Lee. Journal of the American Chemical Society, 126, 4697-4703, 2004.

Patents


  • “Cell Adhesion on Surfaces of Varying Topographies” US 20080241926
  • “Salt and pH tunable Polyelectrolyte Multilayers for uses as bioengineering scaffolds” US 20070224175
  • “Development of Polyelectrolyte Multilayer Coatings for Primary Hepatocyte Cell Culture System” (MSU Invention Number 06-026).
  • “Aptamer Arrays on Polyelectrolyte Multilayer Films” (MSU Invention Number 05-117F).
  • “RNA Arrays on Polyelectrolyte Multilayer Films,” Invention disclosure submitted.

Awards and Honors


  • 2009 DoD Prostate Cancer Postdoctoral Fellowship
  • 2009 Elected to Sigma Xi, Full Member, Harvard Chapter
  • 2007 American Chemical Society ICI Student Award Finalist in Applied Polymer Science
  • 2006 ACS Excellence Award in Polymer Science
  • 2000 Walter and Margaret Yates Memorial Scholarship