Pannier Lab
lab photos 2012
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Pannier Lab Group

Pannier lab group

The long-term goal of the Pannier Lab is to understand and design innovative biomaterials and gene delivery systems to advance biotechnology, diagnostics, fundamental understanding of embryology and tissue development, and regenerative medicine therapies. Research projects within the Pannier Lab are focused in three different themes including nonviral gene delivery, tissue engineering, and protein-cell-biomaterial interactions.

Within the nonviral gene delivery theme, our aim is to determine and understand the mechanisms that render cells responsive to the transfer of genetic material (e.g. DNA), concentrating on the cell microenvironment, the interaction between cells and biomaterials, and the intracellular processes and subsequent signaling involved during nonviral gene delivery. Within the tissue engineering theme, our objective is to develop biomaterial scaffolds and culture systems to understand and promote tissue, organ, and organism development, regeneration, and growth. Within the protein-cell-material interaction theme, projects aim to make use of a novel combinatorial spectroscopic ellipsometry and quartz crystal microbalance with dissipation analytical technique to uncover new and unique information on processes that occur at biomaterial interfaces, which are critical to the performance of biomaterials in biotechnological and therapeutic applications.

The experimental approaches developed in the Pannier Lab provide valuable insights to the fields of gene delivery and biomaterials, with very promising potential for future scientific discovery and translation to therapeutic, biotechnological, and tissue engineering applications.


Dr. Pannier's NSF CAREER Award Highlights



Dr. Tim Martin on the successful defense of his PhD dissertation on April 18, 2014!

Abby Kelly for winning the UNL Spring Graduate Research Fair Poster Competition, April, 2014.

Dr. Tadas Kasputis on the successful defense of his PhD dissertation on March 20, 2014!

Cady Sargus-Patino successfully defended her Master's Thesis on Nov. 15, 2013.

Martin TM, Wysocki BJ, Beyersdorf JP, Wysocki TA, Pannier AK. 2014. "Integrating Mitosis, Toxicity, and Transgene Expression in a Telecommunications Packet-Switched Network Model of Lipoplex-Mediated Gene Delivery." Biotechnology and Bioengineering. (in press) DOI: 10.1002/bit.25207.

Martin TM, Plautz SA, Pannier AK. 2013. "Network analysis of endogenous gene expression profiles after PEI-mediated DNA delivery." The Journal of Gene Medicine. 15(3-4):142-154.

Kasputis T, Koenig M, Schmidt D, Sekora D, Rodenhausen KB, Eichhorn K-J, Uhlmann P, Schubert E, Pannier AK, Schubert M, and Stamm M. 2013. “Slanted Columnar Thin Films Prepared by Glancing Angle Deposition Functionalized with Polyacrylic Acid Polymer Brushes”. Journal of Physical Chemistry, Part C. 117(27): 13971–13980.

Sargus-Patino CN, Wright EC, Plautz SA, Miles JR, Vallet JL and Pannier AK. 2013. “In vitro development of pre-implantation porcine embryos using alginate hydrogels as a three-dimensional matrix”.  Reproduction, Fertility and Development, (in press) doi: 10.1071/RD13008.