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BioMechanics and Materials Laboratory

Brain and Skull Modeling


 Modeling and simulation activities are becoming increasingly important in the area of brain biomechanics with application to primary blast injury (PBI). Although current FE head models include a detailed geometrical description of the head's intracranial contents, there is a crucial lack of material models for the brain which are appropriate to use in blast scenarios analysis, i.e. over a large strain/ very high frequency range.

Brain Schematics Photo

Main Studies

  • A new hyper-viscoelastic model is presented that covers the dynamic behavior of the brain tissue in a large strain/very high frequency range, applicable for blast scenarios. Results from published experiments with a high strain amplitude and frequencies ranging from 100 to 6320Hz and 100kHz to 10MHz are used. The model is formulated in terms of a large strain viscoelastic framework and considers linear viscous deformations in combination with non-linear hyperelastic behavior. The material parameters are determined using Genetic Algorithms(GAs) optimization technique. This hyper-viscoelastic model is readily applicable in 3D head models in order to predict the brain's dynamic responses due to blast loadings.
  • Study on the influence of head heterogeneity on the brain's dynamic responses due to blast/impact load and blast-wave mitigation capability of CSF/dura/pia maters
  • Study on the mechanical behavior of brain tissue due to the shock wave and impact loads with similar peak pressure but different time scale of loading

Research Highlights

Maxwell viscoelastic models for brain tissue over high frequencies

Storage (G') and Loss (G") modulus and magnitude of complex shear modulus (|G*|) vs. frequency - experimental data and prediction of the Maxwell model (experimental sources: Nicolle et al., 2005& Lippert et al., 2004)


Ogden hyperelastic model for brain tissue over large strains


Modeling of the nonlinear elastic behavior of brain tissue by using a two order Ogden hyperelastic model ( experimental source: Franschini et al., 2004)

Dynamic Responses of the Brain Tissue


Dynamic responses of the brain tissue at different frequency ranges of 100Hz-6320Hz and 100kH-10MHz due to blast loading

Dynamic Responses of the Brain Tissue


Dynamic responses of the brain tissue at blast loading (elastic Dura and Pia and without Pia and Dura)- brain material model- hyperviscoelastic with the frequency range of 100kHz - 10MHz