Impulsive Pressurization of Neuronal CellsBased on the assumption that blast-induced overpressure, or high stress impulse, is the main cause of TBI, we investigated the effects of impulsive pressurization on neuronal cell functions. A novel impulsive pressurization apparatus capable of controlling pressure level and duration time has been built using the Kolsky bar set-up. By examining axon shape change, cell apoptosis, and neuronal cell marker (MAP2) gene expression, we expect to reveal the cell/molecular changes under pressurization. More »
Actin cytoskeleton in neuronal cells damaged at 2 MPa pressurization (Actin: Red, Nuclei: Blue) More »
Neuronal differentiation of SH-SY5Y cells is facilitated by retinoic acid. The effect of incubation with 10 μM retinoic acid (RA) - after 7 days neuroblastoma cells resemble normal neuronal phenotype.More »
Effect of impulsive pressure level on the viability and growth rate of SH-SY5Y cells. More »
Blast Cellular Mechanics focuses on identifying the mechanical properties of neuronal brain cells, especially in blast loading conditions. This research is being done by using a Kolsky bar set-up to perform controlled pressure bursts then analyzing cell deformation.