Angela K. Pannier, Ph.D.

Swarts Family Chair of Biological Systems Engineering
Professor of Biomedical Engineering

Academic Degrees

  • Ph.D., Biological Sciences, Northwestern University
  • M.S., Biological Systems Engineering, University of Nebraska-Lincoln
  • B.S., Biological Systems Engineering, University of Nebraska-Lincoln


  • 60% Reseach
  • 40% Teaching

Curriculum Vitae (CV):

Areas of Research and Professional Interest

  • Nonviral Gene Delivery
  • Protein-Cell-Biomaterial Interactions
  • Tissue Engineering
  • Stem Cell Differentiation
Teaching Interests


  • Segura T, Shea LD, Pannier AK, Bengali Z, Jang JH, Chung P, and Anderson B. Controlled surface-associated delivery of genes and oligonucleotides. U.S. Patent No. 7,029,697. April 18, 2006.
  • Pannier AK, Schubert M, Hofmann T, Kasputis TJ, Herzinger CM, Woollam JA. Method to obtain micrographs of transparent or semi-transparent specimens using anisotropy contrast. U.S. Patent No. 10,026,167. July 17, 2018.

About Angela K. Pannier

Angela K. Pannier is the Maxcy Professor of Agriculture and Natural Resources in the Department of Biological Systems Engineering, with a Courtesy Appointment in the Mary and Dick Holland Regenerative Medicine Program at the University of Nebraska Medical Center. 

Pannier’s research is focused in engineering systems and biomaterials for cell and gene therapies. Her lab has pioneered the use of a corn protein, zein, for use as an oral DNA vaccine platform and is now developing new natural materials derived from commensal gut bacteria as oral delivery platforms. Pannier has received funding from the American Heart Association (Scientist Development Grant), National Science Foundation (CAREER Award and MRIs), U.S. Department of Agriculture, and industry. 

Pannier is active in many societies (BMES, AIChE, ASGCT), serves as a reviewer for over 50 different journals and funding agencies (including NIH and NSF), and serves on the editorial board for two journals: Experimental Biology and Medicine and Regenerative Medicine Frontiers. In 2019 Pannier was awarded the Presidential Early Career Award for Scientist and Engineers from the U.S. White House Office of Science and Technology Policy; Pannier is the first Nebraskan to receive this honor. 

Most recently, Pannier was awarded the 2020 Gamma Sigma Delta Outstanding Research Award and the 2020 College of Engineering Outstanding Research and Creative Activity award. Pannier has also been awarded the college-wide Outstanding Graduate Mentor Award and the university-wide Outstanding Undergraduate Research Mentor Award (she has mentored over 40 undergraduates in her lab). Pannier has also served on and led various departmental, college and university committees, and she most recently co-chaired the university-wide N2025 Strategic Planning team in 2019.  She was selected as a Big Ten Academic Alliance Academic Leadership Program Fellow for the 2019-2020 academic year. 

Honors and Awards

  • Big Ten Academic Alliance Academic Leadership Program Fellow (2019-2020)
  • UNL College of Engineering Faculty Research and Creative Activity Award (2020)
  • UNL Gamma Sigma Delta Outstanding Researcher Award (2020)
  • UNL College of Engineering Holling Family Master Teacher Award (2019)
  • Presidential Early Career Award for Scientist and Engineers (PECASE, awarded in 2019 for 2017)
  • UNL Parents Association Teaching Award (2018)
  • National Institutes of Health Director’s New Innovator Award (2017)
  • UNL Outstanding Undergraduate Research Mentor Award (2017)
  • UNL College of Engineering Tau Beta Pi Distinguished Teaching Award (2017)
  • UNL Darrell W. Nelson Excellence in Graduate Student Advising Award (2016)

Selected Publications

Refereed Journal Articles

  1. Kozisek T, Hamann A, Nguyen A, Miller M, Plautz S, Pannier AK. 2020. High-Throughput Screening of Clinically Approved Drugs that Primer Nonviral Gene Delivery to Human Mesenchymal Stem Cells (Epub ahead of print).
  1. Hamann A, Thomas AK, Kozisek T, Farris E, Lück S, Zhang Y, Pannier AK. 2020. Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection. Experimental Biology and Medicine 245(7): 606-619.
  2. Walsh SC, Miles JR, Yao L, Broeckling CD, Rempel LA, Wright-Johnson EC, Pannier AK. 2020. Metabolic compounds within the porcine uterine environment are unique to type of conceptus present during the early stages of blastocyst elongation. Molecular Reproduction and Development 87(1):174-190.
  3. Hamann A, Nguyen A, Pannier AK. 2019. Nucleic acid delivery to mesenchymal stem cells: a review of nonviral delivery methods and applications. Journal of Biological Engineering. 13:7. 
  4. Mantz A, Rosenthal A, Farris E, Kozisek T, Bittrich E, Nazari S, Schubert E, Schubert M, Stamm M, Uhlmann P, Pannier AK. 2019. Free polyethylenimine enhances substrate-mediated gene delivery on titanium substrates modified with RGD-functionalized poly(acrylic acid) brushes. Frontiers in Chemistry: Poly. Chemistry. 7:51.
  5. Mantz A and Pannier AK. 2019. Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery. Experimental Biology and Medicine. 244(2):100-113.
  6. Hamann A, Broad K, Nguyen A, Pannier AK. 2019. Mechanisms of unprimed and dexamethasone-primed nonviral gene delivery to human mesenchymal stem cells. Biotechnology and Bioengineering. 116(2):427-443.
  7. Farris E, Heck K, Lampe AT, Brown DM, Ramer-Tait A, and Pannier AK. 2018. Oral non-viralgene delivery for applications in DNA vaccination and gene therapy. Current Opinion in Biomedical Engineering. 7:51-57
  8. Erickson AG, Laughlin TD, Romereim SM, Sargus-Patino CN, Pannier AK, Dudley AT. 2018. A tunable, three-dimensional in vitro culture model of growth plate cartilage using alginate hydrogel scaffolds.  Tissue Engineering, Part A. 24(1-2): 94-105.
  9. Rosenthal A, Mantz A, Bittrich E, Schubert E, Schubert M, Stamm M, Pannier AK, Uhlmann P. 2018. Biofunctionalization of Titanium Substrates Using Nanoscale Polymer Brushes with Cell Adhesion Peptides. J Physical Chemistry: B. 122 (25): 6543-6550.