Srivatsan Kidambi

Contact Information:

City Campus (Lincoln)
207F OTHM
(402) 472-4443
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Personal Links:

FOCμS LAB

Associate Professor and Graduate Chair

Academic Degrees

  • Postdoctoral Research Fellow, Harvard Medical School and Massachusetts General Hospital, 2009
  • Ph.D., Chemical Engineering and Materials Science, Michigan State University, 2007
  • M.S., Chemistry, Michigan State University, 2002
  • B.S., Chemistry, University of Madras, India, 1999



Areas of Research and Professional Interest

  • Liver Tissue Engineering
  • Cancer Tissue Engineering
  • Biomimetic Models of Aging Brain
  • Nano-scale Drug Delivery System for Gene Therapy

Research Profiles:

Inventions/Patents

  • “Cell Adhesion on Surfaces of Varying Topographies” US 20080241926
  • “Salt and pH tunable Polyelectrolyte Multilayers for uses as bioengineering scaffolds” US 20070224175
  • “Development of Polyelectrolyte Multilayer Coatings for Primary Hepatocyte Cell Culture System” (MSU Invention Number 06-026).
  • “Aptamer Arrays on Polyelectrolyte Multilayer Films” (MSU Invention Number 05-117F).

Courses Taught

About Srivatsan Kidambi

Dr. Kidambi is an Associate Professor (tenured) in the University of Nebraska-Lincoln. He has a broad background and proven track record in the areas of tissue engineering, biomaterials, drug delivery, liver biology and neuroscience. His group researches on developing in vitro models of tissues (liver, brain, cancer, cardiac) to understand the role of the tissue microenvironment on disease progression. Dr.Kidambi's lab also focuses on engineering liposome-based nanoparticles as drug delivery vehicle for miRNA and small drug molecule targeted delivery. The lab  studies fundamental aspects of these phenomena and apply what we learn to manipulate cells of various systems including brain, liver, and tumor. The work in his lab integrates polymer and biomaterials science and tissue engineering together with traditional cell and molecular biology techniques. The group published the first study demonstrating the need for physical intimacy between stromal cells and tumor cells to develop drug resistance pathways (Nature Scientific Reports, 2015). His group laid the groundwork, i.e. demonstrate the role of stiffness in driving functional and metabolic changes in hepatocytes, which lends well to our future studies aimed at understanding the role of stiffness in regulating metabolic changes in liver. The lab has developed in vitro tissue engineering models of liver and brain that mimics the in vivo physiology (RSC Advances, 2016; Nanoscale, 2015; PNAS, 2010; Adv Func Materials, 2008). The lab is also interested in developing miRNA based therapeutics and have published innovative drug delivery platforms capable of temporal and spatial releases of drug combinations (Oncotarget, 2016; J Biomed Nanotech, 2016; Nature Scientific Reports, 2015). The lab also has three patents in the works demonstrating the translational viability of the platforms developed in our lab. In 2015, Dr. Kidambi was selected for the UNL Emerging Innovator Award. Dr. Kidambi has trained and supervised over 50 trainees including BS, MS, graduate students, post-doctoral associates, and technicians and currently has 5 graduate students and 7 under graduate students in his lab.

Experience

Projects:

  • Engineering of Tissue Microenvironment- Cancer, Brain, Liver
  • Nano-scale Drug Delivery System for Gene Therapy

Honors and Awards

  • 2013 Young Investigator Award, International Symposium on the Cells of the Hepatic Sinusoid
  • 2009 DoD Prostate Cancer Postdoctoral Fellowship
  • 2009 Elected to Sigma Xi, Full Member, Harvard Chapter
  • 2007 American Chemical Society ICI Student Award Finalist in Applied Polymer Science
  • 2006 ACS Excellence Award in Polymer Science
  • 2000 Walter and Margaret Yates Memorial Scholarship

Selected Publications

    1. Astrogliosis in a Dish: Substrate Stiffness Induces Astrogliosis in Primary Rat Astrocytes” Christina Wilson, Stephen Hayward, Srivatsan Kidambi*,  RSC Advances, 2016 (Impact Factor = 3.84) 
    2. "Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells”, Stephen Hayward, Christina Wilson, Srivatsan Kidambi*OncoTarget2016  (Impact Factor = 6.4)
    3. Targeted Delivery of MicroRNA-125a-5p by Engineered Lipid Nanoparticles for the Treatment of HER2 positive Metastatic Breast Cancer”, Stephen Hayward, David Francis, Parviz Kholmatov, Srivatsan Kidambi*,  Journal of Biomedical Nanotechnology2016 doi: 10.1166/jbn.2016.2194 (Impact Factor = 5.4)
    4. Ionic Driven Embedment of Hyaluronic Acid Coated Liposomes in Polyelectrolyte Multilayer Films for Local Therapeutic Delivery”, Stephen Hayward, David Francis, Matthew Sis, Srivatsan Kidambi*,  Nature Scientific Reports2015, doi: 10.1038/srep14683 (Impact Factor = 5.6)
    5. Substrate elasticity regulates primary hepatocytes functions”, Vaishaali Natarajan, Eric Berglund, Dorothy Chen, Srivatsan Kidambi*,  RSC Advances, 2015, doi: 10.1039/C5RA15208A (Impact Factor = 3.84)
    6. In vitro Co-cultures of Breast Cancer Cells and Stromal Cells to Emulate Tumor Progression and miRNA Profiles of Clinical Conditions”, Amita Daverey, Karleen Brown, Srivatsan Kidambi*, Langmuir2015 doi: 10.1021/acs.langmuir.5b02227  (Impact Factor = 4.0)
    7. Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation” Amita Daverey, Allison Drain, Srivatsan Kidambi*,  Nature Scientific Reports2015 doi: 10.1038/srep13744 (Impact Factor = 5.6)
    8. “Mitochondrial Dysfunction and Loss of Glutamate Uptake in Primary Astrocytes Exposed to Titanium Dioxide Nanoparticles”, Christina Wilson, Vaishaali Natarajan, Stephen Hayward, Oleh Khalimonchuk, Srivatsan Kidambi* Nanoscale, 2015 doi: 10.1039/C5NR03646A  (Impact Factor = 7.4)
    9. “Mitochondrial Dysregulation and Loss of Hepatic Functions due to Chronic Exposure to Titanium dioxide Nanoparticles to Primary Hepatocytes”, Vaishaali Natarajan, Christina Wilson, Stephen Hayward, Srivatsan Kidambi*PLOS One, 2015. doi: 10.1371/journal.pone.0134541 (Impact Factor = 3.53)
    10. Dye-doped silica encapsulated magnetic nano-assemblies for dual optical/MRI imaging and hyperthermia", Sunil Kumar, Dhirendra Bahadur, Amita Daverey, Vahid Khalilzad-Sharghi, Niroj Sahu, Niroj; Srivatsan Kidambi, Shadi Othman,  RSC Advances, , 5, 53180-53188, 2015.  doi: 10.1039/C5RA07632C (Impact Factor = 3.84)
    11. FMR1 Deficiency Alters Self-Renewal, Proliferation, and Pluripotency of Mouse Embryonic Cells”, Shyam Sundhar Bale; Nima Saeidi; Srivatsan Kidambi; Martin Yarmush; Monica Casali, NanoLife, 5(2), 15500, 2015. doi: 10.1142/S1793984415500038
    12. Engineering of highly controlled in vitro co-culture model to study the mesenchymal stem cells mediated signaling in breast cancer cells”,  Amita Daverey, Allison Drain, Karleen Drain, Srivatsan Kidambi*,  Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; Cancer Res 2014; 74 (19 Suppl). doi:10.1158/1538-7445.AM2014-3303
    13. Topography Mediated Regulation of HER-2 Expression in Breast Cancer Cells” Amita Daverey, Austin Mytty, Srivatsan Kidambi *, NanoLife, 2(3), 12410,  2012 doi: 10.1142/S1793984412410097
    14. Propofol induces MAPK/ERK cascade dependant expression of c-Fos and Egr-1 in rat hippocampal slices” Srivatsan Kidambi*, Joel Yarmush, Yevgeny Berdichevsky, Sangeetha Kamath, Wayne Fong, Joseph SchianodiCola, BMC Research Notes, 17(3), 201-206, 2010
    Prior UNL
    1. Oxygen-Mediated Enhancement of Metabolism, Functional Polarization, Gene Expression an Drug Clearance in Cocultures of Primary Hepatocytes” Srivatsan Kidambi, Eric Novik, Ruby Yarmush, Piyun Chao, Martin Yarmush, Yaakov Nahmias, Proceedings of the National Academy of Science, 106(37), 15714-9, 2009.
    2. Propofol induces a Dose-Dependent Alteration in the Expression of c-Fos and Egr-1 in Neuronal Cells” Srivatsan Kidambi*, Joel Yarmush, Wayne Fong, Sangeetha Kamath, Joseph SchianodiCola, Yaakov Nahmias, NeuroReport, 20(7), 657-662, 2009.
    3. Tunable Resistive m-dPEG Acid Patterns on Polyelectrolyte Multilayers at Physiological Conditions:  Template for Directed Deposition of BiomacromoleculesSrivatsan Kidambi, Christina Chan*, Ilsoon Lee*., Langmuir,24(1),224-30, 2008.
    4. Patterned Co-culture of Neurons and Astrocytes on Polyelectrolyte Multilayer Films for Studying Astrocyte Mediated Oxidative Stress in Neurons” Srivatsan Kidambi, Ilsoon Lee, Christina Chan. Advanced Functional Materials, 18, 294-301, 2008.
    5. Selective Adhesion of Primary Hepatocytes on Polyelectrolyte Multilayers: Template for Patterned Cell Co-culture” Srivatsan Kidambi, Lufang Sheng, Mehmet Toner, Martin Yarmush, Ilsoon Lee, Christina Chan. Macromolecular Biosciences, 7(3), 344-53, 2007.
    6. “Cell Adhesion on Polyelectrolyte Multilayer coated PDMS Surfaces with Varying Topographies” Srivatsan Kidambi, Natasha Udpa, Stacey Schroeder, Ilsoon Lee, Christina Chan. Tissue Engineering, 13 (8), 2105-2117, 2007.
    7. Salt tunable m-dPEG Acid Patterns on Polyelectrolyte Multilayer - Templates for Directed Deposition of Macromolecules” Srivatsan Kidambi, Ilsoon Lee, Christina Chan.  Polymer Preprints, 47(1), 41-42, 2006.
    8. Polyelectrolyte Multilayer as Bioactive Surface for Cell Adhesion” Srivatsan Kidambi, Ilsoon Lee, Christina Chan.  Polymer Preprints 46(2), 1271-1272, 2005.
    9. "Selective Primary Hepatocyte Adhesion on Polyelectrolyte Multilayer: Template for Patterned Cell Co-culture” Srivatsan Kidambi, Ilsoon Lee, Christina Chan.  AICHE Preprint, 2004.
    10.  “Engineering Polyelectrolyte Multilayer (PEM) Surfaces to Create Cell Resistant and Adhesive Surfaces” Srivatsan Kidambi, Ilsoon Lee, Christina Chan.  Polymer Preprints 45(1), 88-89, 2004.
    11. Controlling Primary Hepatocyte Adhesion and Spreading on Protein Free Polyelectrolyte Multilayer Films” Srivatsan Kidambi, Ilsoon Lee, Christina Chan. Journal of the American Chemical Society126 (50), 16286 -16287, 2004.
    12. Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Templates” Srivatsan Kidambi, Christina Chan, Ilsoon Lee. Journal of the American Chemical Society126, 4697-4703, 2004.