Our major research interest lies in the engineering of biological components and systems for biotechnological applications, including bio-based chemical production and biomedical investigations. Along the process, we are also keen to unravel underlying fundamental genetic, biochemical, and biophysical principles that can guide future studies and engineering. Research in our group has three thrusts, including protein/enzyme engineering, biopathway design/engineering, cell and cellular organelle engineering. We build and apply synthetic biology tools to rewire or rewrite the genetic information so that a cell can be programmed to perform defined tasks. We apply systems biology methods to gain holistic view/prediction about the cellular performance and response to genetic manipulation.