ONE Lab: Patents and Publications

  • Caparaso SM, Redwine AL, Wachs RA. Engineering a multicompartment in vitro model for dorsal root ganglia phenotypic assessment. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2023 Jun 16. 
  • Lillyman DJ, Barnett EC, Miller TJ, Wachs RA. Application of microcomputed tomography to calculate rat intervertebral disc volume as a surrogate measure of degeneration. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 2023; Feb 27:1-7.
  • Lee FS, Ney KE, Richardson AN, Oberley-Deegan RE, Wachs, RA. Encapsulation of manganese porphyrin in chondroitin sulfate-A microparticles for long term reactive oxygen species scavenging. Cellular and Molecular Bioengineering Journal. 2022; 14:1-7. 
  • Wachs RA, Wellman SM, Porvasnik SL, Lakes EH, Cornelison RC, Song YH, Allen KD, Schmidt CE. Apoptosis-Decellularized Peripheral Nerve Scaffold Allows Regeneration Across Nerve Gap. Cells Tissues Organs. 2022 Aug 26:1-1. 
  • Lillyman DJ, Lee FS, Barnett EC, Miller TJ, Alvaro ML, Drvol HC, Wachs RA. Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats. JOR Spine. 2022; 14:e1212
  • Piening LM, and Wachs RA. Matrix-Bound Nanovesicles: What Are They and What Do They Do?. Cells Tissues Organs 2022 Feb 15:1-3. 
  • Piening LM, Lillyman DJ, Lee FS, Lozano AM, Miles JR, Wachs RA. Injectable Decellularized Nucleus Pulposus Tissue Maintains Neuroinhibitory Properties. JOR spine. 2022; 5(1):e1187.  
  • Bousalis D, Lacko CS, Hlavac N, Alkassis F, Wachs RA, Mobini S, Schmidt CE and Kasahara H (2020) Extracellular Matrix Disparities in an Nkx2-5 Mutant Mouse Model of Congenital Heart Disease. Front. Cardiovasc. Med. 2020; 7:93. 
  • Agrawal NK, Allen P, Song YH, Wachs RA, Du Y, Ellington AD, Schmidt CE. Oligonucleotide-functionalized hydrogels for sustained release of small molecule (aptamer) therapeutics. Acta Biomaterialia. 2020;102:315-325. 
  • McCrary MW, Vaughn NE, Hlavac N, Song YH, Wachs RA, Schmidt CE. Novel Sodium Deoxycholate-Based Chemical Decellularization Method for Peripheral Nerve. Tissue Engineering Part C: Methods. 2020; 26(1):23-36. 
  • Romereim SM, Johnston CA, Redwine AL, Wachs RA. Development of an in vitro intervertebral disc innervation model to screen neuroinhibitory biomaterials. Journal of Orthopaedic Research. 2020 May;38(5):1016-26.
  • Agrawal NK, Allen P, Song YH, Wachs RA, Du Y, Ellington AD, Schmidt CE. Oligonucleotide-functionalized hydrogels for sustained release of small molecule (aptamer) therapeutics. Acta Biomaterialia. 2020 Jan 15;102:315-25.
  • McCrary MW, Vaughn NE, Hlavac N, Song YH, Wachs RA, Schmidt CE. Novel Sodium Deoxycholate-Based Chemical Decellularization Method for Peripheral Nerve. Tissue Engineering Part C: Methods. 2020 Jan 1;26(1):23-36.

  • Cornelison RC, Wellman SM, Park JH, Porvasnik SL, Song YH, Wachs RA, Schmidt CE. Development of an apoptosis-assisted decellularization method for maximal preservation of nerve tissue structure. Acta biomaterialia. 2018 Sep 1;77:116-26.

  • Jacobs BY, Lakes EH, Reiter AJ, Lake SP, Ham TR, Leipzig ND, Porvasnik SL, Schmidt CE, Wachs RA, Allen KD. The Open Source GAITOR Suite for Rodent Gait Analysis. Scientific reports. 2018 Jun 28;8(1):9797.

  • Cerqueira SR, Lee YS, Cornelison RC, Mertz MW, Wachs RA, Schmidt CE, Bunge MB. Decellularized peripheral nerve supports Schwann cell transplants and axon growth following spinal cord injury. Biomaterials. 2018 Sep 1;177:176-85.

  • Ledet EH, Wachs RA, Cole KP, Fiorella D. Awarded May 2017. PCT/US2013/024706. Sensor System, Implantable Sensor and Method for Remote Sensing of a Stimulus In Vivo.

  • Wachs RA, Hoogenboezem EN, Huda HI, Xin S, Porvasnik, SL, Schmidt CE. Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering. The Spine Journal. 2017; 17(3):435-444.

  • Schmidt CE, Cornelison RC, Wachs RA. Submitted July 2016. PCT/US2016/42273. Apoptosis-Assisted Method of Tissue Decellularization.

  • Ledet EH, Peterson JM, Wachs RA, Grabowsky MBM, Glennon JC, DiRisio DJ. Direct Measure of Cervical Interbody Forces In Vivo: Load Reversal After Plating. The Spine Journal. 2016; 16(10S):S238-9.

  • Wachs RA, Ellstein D, Drazan J, Healey CP, Uhl RL, Connor, KA, Ledet EH. Elementary implantable force sensor—for smart orthopaedic implants. Advances in Biosensors and Bioelectronics. 2013; 2(4).

  • Ledet EH, D’Lima D, Westerhoff P, Szivek J, Wachs RA, Bergmann G. Implantable sensor technology: from research to clinical practice. J Am Acad Orthop Surg,. 2012; 20(6):383-392.

  • Wachs RA, Grabowsky MBM, Glennon J, Ledet EH. In Vivo Loads in the Cervical Spine: A preliminary investigation using a force-sensing implant. The Spine Journal. 2012; 12(9), S141.

  • Wachs RA, Michna VM, Ledet EH. Three-dimensional morphometry of human cervical endplates. The Spine Journal. 2012; 12(9), S141-S142.

  • Grabowsky MBM, Pallotta NA, Connelly MW, Van Etten B, MacDonald RA, Alley M, Glennon JC, Dubin AH, German JW, Uhl RL, Ledet EH. The potential role of extensor muscle fatigue in the onset of intervertebral disc degeneration: A novel in vivo model. The Spine Journal. 2010; 10(9S):74S-5S.

  • MacDonald RA, Voge CM, Kariolis M, Stegemann JP. Carbon nanotubes increase the electrical conductivity of fibroblast-seeded collagen hydrogels. Acta Biomaterials. 2008 Jul;4:1583-1592.

  • Voge CM, Kariolis M, MacDonald RA, Stegemann JP. Directional conductivity in SWNT-collagen-fibrin composite biomaterials through strain-induced matrix alignment. J Biomed Mater Res A. 2008 Jul;86(1):269-77.

  • Laraia K, Leone N, MacDonald RA, Blanchet TA. Effect of water and serum absorption on wear of unirradiated and crosslinked UHMWPE orthopedic bearing materials. Tribology Transactions. 2006; 49: 338-346.

  • MacDonald RA, Laurenzi BF, Viswanathan G, Ajayan PM, Stegemann JP. Collagen-carbon nanotube composite materials as scaffolds in tissue engineering. J Biomed Mater Res A. 2005 Sep 1;74(3):489-96.

  • Stegemann, JP, MacDonald RA, Laurenzi BF. Provisional Patent (2004). Tissue Substitutes Compromising Living Cells, Hydrogel Matrix and Carbon Nanotubes.

A full list of publications can be found at: Google Scholar - https://scholar.google.com/citations?user=rU-dVMEAAAAJ&hl=en.