Education

• Ph.D., Dept. of Fiber and Polymer Science, Seoul National University, Korea, 1999
• M.S., Dept. of Fiber and Polymer Science, Seoul National University, Korea, 1994
• B.S., Dept. of Textile Engineering, Seoul National University, Korea, 1992

Employment

• University of Nebraska-Lincoln, Assistant Professor, 2008-present
• Pennsylvania State University College of Medicine, Instructor, 2006-2008
• Pennsylvania State University College of Medicine, Post-doc., 2002-2006
• Korea Institute of Science & Technology (KIST), Korea, Post-doc., 1999-2002

Current Research

Understanding and regulating cell responses to biomaterials and biophysical signals is crucial to the success of various biomedical applications including tissue engineering, implants, cell-based biosensors, etc. Our overall research focus is on the utilization of biomaterial surface engineering/patterning tools (nanotexturing, surface energy tuning, chemical or topographic micro/nanopatterning) in combination with biophysical stimuli (shear stress, mechanical strain, high pressure loading) to regulate functions of stem cells, musculoskeletal cells, neuronal cells, etc. One of the ongoing researches in the lab investigates nanotopographic regulation of osteoblastic and stem cell behavior considering the biomimetic role of nanotopographic interfaces. Using nanoscale topographies fabricated by polymer demixing and lithographic techniques, we aim to regulate integrin mediated osteoblast focal adhesion and downstream cell signaling, stem cell differentiation toward an osteoblastic lineage, and bone and stem cell mechanosensitivity in response to biophysical signals such as fluid flow induced shear stress.

Publications

• Joshua D. Salvi,* Jung Yul Lim,* Henry J. Donahue. Increased mechanosensitivity of cells cultured on nanotopographies. J. Biomech.2010;43:3058-3062 (*: contributed equally).
• Joshua D. Salvi, Jung Yul Lim, Henry J. Donahue. Finite element analyses of fluid flow conditions in cell culture. Tissue Eng. C. 2010;16:661-670.
• Jung Yul Lim. Topographic control of cell response to synthetic materials. Tissue Eng. Regen. Med. 2009;6:365-370.
• Jung Yul Lim, Michael C. Shaughnessy, Zhiyi Zhou, Hyeran Noh, Erwin A. Vogler, Henry J. Donahue. Surface energy effects on osteoblast spatial growth and mineralization. Biomaterials 2008;29:1776-1784.
  
• Xiaomei Liu, Jung Yul Lim, Henry J. Donahue, Ravi Dhurjati, Andrea M. Mastro, Erwin A. Vogler. Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials 2007;28:4535-4550 (‘Leading Opinion’ paper).
  
• Joshua C. Hansen, Jung Yul Lim, Li-Chong Xu, Christopher A. Siedlecki, David T. Mauger, Henry J. Donahue. Effect of surface nanoscale topography on elastic modulus of individual osteoblastic cells as determined by atomic force microscopy. J. Biomech. 2007;40:2865-2871.
  
• Jung Yul Lim, Henry J. Donahue. Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning. Tissue Eng. 2007;13:1879-1891.
  
• Jung Yul Lim, Andrea D. Dreiss, Zhiyi Zhou, Joshua C. Hansen, Christopher A. Siedlecki, Robert W. Hengstebeck, Juan Cheng, Nicholas Winograd, Henry J. Donahue. The regulation of integrin mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials 2007;28:1787-1797 (Figure 7 selected for ‘The first limited edition of Biomaterials Poster featuring the best images from articles published in 2007 volume’).
  
• Jung Yul Lim, Joshua C. Hansen, Christopher A. Siedlecki, Robert W. Hengstebeck, Juan Cheng, Nicholas Winograd, Henry J. Donahue. Osteoblast adhesion on poly(L-lactic acid)/polystyrene demixed thin film blends: Effect of nanotopography, surface chemistry, and wettability. Biomacromolecules 2005;6:3319-3327.
  
• Jung Yul Lim, Joshua C. Hansen, Christopher A. Siedlecki, James Runt, Henry J. Donahue. Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces. J. R. Soc. Interface 2005;2:97-108.
  
• Young Shin Kim,* Jung Yul Lim,* Henry J. Donahue, Tao Lu Lowe. Thermoresponsive terpolymeric films applicable for osteoblastic cell growth and noninvasive cell sheet harvesting. Tissue Eng. 2005;11:30-40 (*: Contributed equally).
  
• Jung Yul Lim, Amanda F. Taylor, Zhongyong Li, Erwin A. Vogler, Henry J. Donahue. Integrin expression and osteopontin regulation in human fetal osteoblastic cells mediated by substratum surface characteristics. Tissue Eng. 2005;11:19-29.
• Jung Yul Lim, Henry J. Donahue. Biomaterial characteristics important to skeletal tissue engineering. J. Musculoskelet. Neuronal Interact. 2004;4:396-398.
  
• Jung Yul Lim, Xiaomei Liu, Erwin A. Vogler, Henry J. Donahue. Systematic variation in osteoblast adhesion and phenotype with substratum surface characteristics. J. Biomed. Mater. Res. A 2004;68:504-512.