Nicole M. Iverson

Nicole M. Iverson, PhD

Contact Information:
233 L.W. Chase Hall
Lincoln: East Campus
(402) 472-0884
Iverson@unl.edu
Email    Twitter icon   
Personal Links:
Iverson Lab
Professional Memberships:
Biomedical Engineering Society
Electrochemical Society

Assistant Professor and Biomedical Nanotechnology Specialist
Academic Degrees
  • Ph.D., Biomedical Engineering, University of Medicine and Dentistry of New Jersey and Rutgers University (2009)
  • M.S., Biomedical Engineering, Rutgers University (2005)
  • B.S., Biomedical Engineering, Minor in Mathematics and Chemistry, University of Minnesota, Institute of Technology (2003)
Appointment
  • 50% Research
  • 40% Teaching
  • 10% Service
Areas of Research and Professional Interest
  • Biomedical engineering
  • Nanotechnology
  • Biological sensors
  • Disease development and resistance
  • Reactive oxygen and nitrogen species
Inventions/Patents
  • Iverson NM, Strano MS, Reuel NF, McNicholas TP. Near-infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. 61/878,303 Filing Date: Sept. 16 2013.
  •  Uhrich KE, Moghe PV, Sparks S, Hehir S, Gu L, Iverson N, Plourde NP. Polymeric Micelles for Reducing LDL In Vivo. US 20120219598 A1. Publication Date: Aug. 30 2012.
  •  Moghe PV, Uhrich KE, Iverson N, Plourde N, Wang JZ. Compositions and Methods for Treating Cardiovascular Conditions. US 20110008396 A1. Publication Date: Jan. 13 2011.
Courses Taught
  • BSEN 100: Introduction to Biological Systems Engineering
  • BSEN 317: Introduction to Biomedical Engineering

About Nicole M. Iverson

  Iverson’s research interests include delivery, monitoring and analysis of in vivo nanoparticles that act as biological sensors, DNA-wrapped single wall carbon nanotubes in alginate microparticles, modifying chemical structures of nanoparticles for use in non-invasive intravenous delivery. Iverson was an NIH postdoctoral fellow at the Massachusetts Institute of Technology, she earned a Ph.D. and M.S. degree in biomedical engineering from Rutgers University and a B.S. in biomedical engineering from the University of Minnesota.



Experience

Massachusetts Institute of Technology (2010 – present)
NIH Postdoctoral Fellow 
Advisors: Michael Strano, Gerald Wogan, John Essigmann

  • Delivery, monitoring and analysis of in vivo nanoparticles that act as biological sensors
  • Encapsulate, optimize and analyze DNA-wrapped single wall carbon nanotubes in alginate microparticles
  • Modified chemical structure of nanoparticle to enable noninvasive, intravenous delivery
  • Spearheaded NIH grant-writing effort
  • Trained students and peers in proper in vivo techniques

Rutgers University (2003 – 2010)
NIH Research Fellow
Advisors: Prabhas Moghe, Kathryn Uhrich, Gary Nackman

Graduate Thesis:  Multifunctional nanoassemblies that increase highly oxidized LDL efflux while inhibiting highly oxidized LDL uptake, cytokine signaling and matrix metalloproteinase activation

  • Developed protocol and independently performed animal study to test the in vitro findings in an in vivo model
  • Tested and analyzed biological effects of anionic nanoparticles on a cultured cell line with multiple biochemical, genetic, and fluorometric assays
  • Designed and implemented RT2-PCR and PCR microarray based gene expression studies; specifically, analyzed atherosclerotic and inflammatory pathways
  • Synthesized, purified and analyzed multifaceted nanoparticles
  • Trained new students in proper lab technique and testing procedures
  • Assisted in writing grants for NSF, NIH and AHA

Mayo Clinic (2006)
Research Internship
Advisor: Gary Sieck

  • Established protocol and mastered technique to label and capture different cell types with laser capture microdissection
  • Mastered quantitative RT-PCR procedure and analysis

 University of Minnesota (2002 – 2003)
Undergraduate Research Assistant                                                                      
Advisor: Jay Zhang

  • Observed and assisted with live animal operations for multiple protocols
  • Researched and tested new techniques of stem cell delivery through a fibrinogen patch into the heart
  • Interpreted data and wrote papers to explain the research for submission as journal articles
  • Cultured cells from research animal

University of Minnesota (2001)
Undergraduate Research Assistant                                                                      
Advisor: Natalia Tretyakova

  • Formulated and customized interstrand DNA cross-linking methods with multiple carcinogenic agents
  • Optimized digestion methods for different compounds
  • Created and ran gel electrophoresis and MALDI-TOF analyses to determine DNA sequences and carcinogenic interference points

Fairview University Hospital, Pharmacy, Minneapolis, MN (2000)
Pharmaceutical Assistant                                                                                      
Advisor: Kathy Johnson

  • Maintained accurate counts and labeling of drug quantities and distribution of pharmaceutical products in double blind clinical trials

Hennepin County Medical Center, Minneapolis, MN (1999)
Student Observer                                                                                                  
Advisor: Timothy Henry

  • Observed human subjects and assisted medical professionals with multiple medical procedures and experimental protocols to investigate cardiac catheterization treatments

Honors and Awards

Massachusetts Institute of Technology

  • NIH Postdoctoral Fellowship (2010 – 2013)
  • Listed on CNN’s Top 10 Ideas (2013)
  • Center for Environmental Health Sciences poster competition award (2013)
  • MIT Post Doctorate Association poster competition award (2013)
  • Aspen Cancer Conference, invited participant (2013)
  • MIT Biological Engineering Retreat, invited participant (2013)
  • Articles describing novel in vivo sensor in NanotechWeb, Neue Zuricher Zeitung, MIT News (2013)
  • Incorporation of sensor technology into exhibit, MIT Museum (2013)

 Rutgers University

  • American Heart Association Fellowship (2008 – 2009)
  • NIH Biotechnology Fellowship (2005 – 2008)
  • GAANN Fellowship (2004 – 2005)
  • Whitaker Foundation Fellowship (2003 – 2004)

 University of Minnesota

  • Lillehei Heart Association Grant (2002 – 2003)
  • National Merit Scholarship (1999 – 2003)
  • Iron Range Scholarship (1999 – 2003)
  • American Heart Association Grant (1999)

Selected Publications

  • Iverson NM, Biskar G, Farias E, Ivanov V, Wogan GN, Strano MS, Carbon nanotube sensor encapsulation platform – characterization and optimization. Journal of Biomedical Nanotechnology, 2016, 12:1035-1047.
  • Bisker G, Dong J, Park HD, Iverson NM, Ahn J, Nelson JT, Landry MP, Kruss S, Strano MS, Protein-targeted corona phase molecular recognition. Nature Communications, 2016, 7:10241.
  •  Giraldo JP, Landry MP, Kwak S, Jain R, Wong MH, Iverson NM, Ben-Naim M, Strano MS, A Ratiometric Sensor Using Single Chirality Near-Infrared Fluorescent Carbon Nanotubes: Application to In Vitro Monitoring. Small, 2015, 11(32):3973-3984.
  •  Iverson NM, Strano MS, Wogan GN, In Vivo Delivery of Nitric Oxide Sensing Single Walled Carbon Nanotubes. Current Protocols in Chemical Biology, 2015, 7:93-102.
  •  Biskar G, Iverson NM, Ahn J, Strano MS, A Pharmacokinetic Model of a Tissue Implantable Insulin Sensor. Advanced Healthcare Materials, 2015, 4(1):87-97.
  •  Landry MP, Kruss S, Nelson JT, Bisker G, Iverson NM, Reuel NF, Strano MS, Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona. Sensors, 2014, 14(9):16196-16211.
  •  Ulissi ZW, Sen F, Gong X, Sen S, Iverson NM, Boghossian A, Godoy L, Wogan GN, Mukhopadhyay, Strano MS, Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors. Nano Letters, 2014, 14(8):4887-4894.
  •  Giraldo JP, Landry MP, Faltermeier S, McNicholas TP, Iverson NM, Boghossian AA, Reuel NF, Hilmer AJ, Sen F, Brew J Strano MS, Plant nanobionics approach to augment photosynthesis and biochemical sensing. Nature Materials, 2014, 13(4):400-408.
  •  Iverson NM, Barone PW, Shandell M, Trudell LJ, Sen S, Sen F, Ivanov V, Atolia E, Farias E, McNicholas TP, Reuel N, Parry NMA, Wogan GN, Strano MS, In vivo biosensing via tissue localizable near-infrared fluorescent single walled carbon nanotubes. Nature Nanotechnology, 2013, 8(11):873-880.
  •  Iverson NM, Plourde NM, Sparks SM, Wang J, Patel EN, Shah PS, Lewis DR, Zablocki KR, Nackman GB, Uhrich KE, Moghe PV, Dual use of amphiphilic macromolecules as cholesterol efflux triggers and inhibitors of macrophage athero-inflammation. Biomaterials, 2011, 32(32):8319-8327.
  •  Iverson NM, Sparks SM, Demirdirek B, Uhrich KE, Moghe PV, Controllable inhibition of cellular uptake of oxidized low density lipoprotein: structure-function relationships for nanoscale amphiphilic polymers. Acta Biomaterials, 2010, 6(8):3081-3091.
  •  Iverson N, Plourde N, Chnari E, Nackman G, Moghe PV, Convergence of nanotechnology and cardiovascular medicine: progress and emerging prospects. BioDrugs, 2008, 22(1):1-10.
  •  Wang J, Plourde N, Iverson N, Moghe PV, Uhrich KE, Nanoscale amphiphilic macromolecules as lipoprotein inhibitors: the role of charge and architecture. International Journal of Nanomedicine, 2007, 2(4):697-705.
  •  Zhang J, Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AH, Ugurbil K, Bache RJ. Nitric oxide regulation of myocardial O2 consumption and HEP metabolism. American Journal of Physiology, Heart and Circulatory Physiology, 2005, 288(1):H310-H316.

Recent Presentations

  • Nicole M Iverson, In Vivo Cabon Nanotube Sensors. Electrochemical Society Annual Meeting 2016.
  • Nicole M Iverson, Nitric Oxide Detection Via Carbon Nanotubes. University of Nebraska Regenerative Medicine Symposium 2016.
  • Nicole M Iverson, Carbon Nanotubes as In Vivo Nitric Oxide Sensors. Massachusetts Institute of Technology Biological Engineering Retreat 2013.
  • Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Aspen Cancer Conference 2013.
  • Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Center for Environmental Health Sciences Meeting 2013.
  • Nicole M Iverson, In vivo Delivery of Single-Walled Carbon Nanotubes Acting as Nitric Oxide Sensors. DNA Repair and Mutagenesis Seminar 2013.
  • Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Post Doctorate Association Meeting 2013.