TML - Journal Publications


Journal Publications


2017

Image: Disturbed cyclical stretch of endothelial cells promotes nuclear expression of the pro-atherogenic transcription factor NF-κB
Disturbed cyclical stretch of endothelial cells promotes nuclear expression of the pro-atherogenic transcription factor NF-κB

Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Daeriswyl DC, Drakakis EM, Krams R. Annals of Biomedical Engineering (2017).

PMID: 27796516


2016

Image: Influence of shear stress magnitude and direction on atherosclerotic plaque composition
Influence of shear stress magnitude and direction on atherosclerotic plaque composition

Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E, Krams R. Royal Society Open Science (2016).

PMID: 27853578


Image: Accommodation of the human lens capsule using a finite element model based on nonlinear regionally anisotropic biomembranes
Accommodation of the human lens capsule using a finite element model based on nonlinear regionally anisotropic biomembranes

David G, Pedrigi RM, Humphrey JD. Computer Methods in Biomechanics and Biomedical Engineering (2016).

PMID: 27609339


Image: Development of a synthetic gene network to modulate gene expression by mechanical forces
Development of a synthetic gene network to modulate gene expression by mechanical forces

Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T, Krams R. Scientific Reports (2016).

PMID: 27404994


Image: Comparison between direct and reverse electroporation of cells in situ: a simulation study
Comparison between direct and reverse electroporation of cells in situ: a simulation study

Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M, Krams R. Physiological Reports (2016).

PMID: 27009275


Image: Integration of flow studies for robust selection of mechanoresponsive genes
Integration of flow studies for robust selection of mechanoresponsive genes

Maimari N, Pedrigi RM, Russo A, Broda K, Krams R. Thrombosis and Haemostasis (2016).

PMID: 26842798


2015

Image: Quantification of plaque stiffness by brillouin microscopy in experimental thin cap fibroatheroma
Quantification of plaque stiffness by brillouin microscopy in experimental thin cap fibroatheroma

Antonacci G*, Pedrigi RM*, Kondiboyina A, Mehta VV, Silva R, Paterson C, Krams R, Torok P. Royal Society Interface (2015).

PMID: 26559685


Image: Shear stress-induced atherosclerotic plaque composition in ApoE-/- mice is modulated by connexin37
Shear stress-induced atherosclerotic plaque composition in ApoE-/- mice is modulated by connexin37

Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R, Kwak BR. Atherosclerosis (2015).

PMID: 26342936


Image: Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs
Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

Pedrigi RM*, Poulsen CB*, Mehta VV, Holm NR, Pareek N, Post AL, …, Erik Bøtker H, Falk E, Krams R, de Silva R. Circulation (2015).

PMID: 26179404


Image: Mammalian synthetic biology: emerging medical applications
Mammalian synthetic biology: emerging medical applications

Kis Z, Pereira HS, Homma T, Pedrigi RM, Krams R. Royal Society Interface (2015).

PMID: 25808341


2014

Image: Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma
Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma

Overby DR*, Zhou EH*, Vargas-Pinto R*, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M. Proceedings of the National Academy of Sciences (2014).

PMID: 25201985


Image: Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells
Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells

Braakman ST, Pedrigi RM, Read AT, Smith JA, Stamer WD, Ethier CR, Overby DR. Experimental Eye Research (2014).

PMID: 25128579


Image: Thin-cap fibroatheroma rupture is associated with a fine interplay of shear and wall stress
Thin-cap fibroatheroma rupture is associated with a fine interplay of shear and wall stress

Pedrigi RM, de Silva R, Mehta VV, Bovens SM, Petretto E, Krams R. Arteriosclerosis, Thrombosis, and Vascular Biology (2014).

PMID: 25060797


2013

Image: Systems biology of the functional and dysfunctional endothelium
Systems biology of the functional and dysfunctional endothelium

Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L, Krams R. Cardiovascular Research (2013).

PMID: 23650287


2011

Image: In vitro models for glaucoma research: Effects of hydrostatic pressure
In vitro models for glaucoma research: Effects of hydrostatic pressure

Lei Y*, Rajabi S*, Pedrigi RM, Overby DR, Read AT, Ethier CR. Investigative Ophthalmology and Visual Science (2011).

PMID: 21693606


Image: A model of giant vacuole dynamics in human Schlemm’s canal endothelial cells
A model of giant vacuole dynamics in human Schlemm’s canal endothelial cells

Pedrigi RM, Simon D, Reed A, Stamer WD, Overby DR. Experimental Eye Research (2011).

PMID: 21075103


Image: Computational model of evolving lens capsule biomechanics following cataract-like surgery
Computational model of evolving lens capsule biomechanics following cataract-like surgery

Pedrigi RM, Humphrey JD. Annals of Biomedical Engineering (2011).

PMID: 20665113


2009

Image: Ex vivo quantification of the time course of contractile loading of the porcine lens capsule after cataract-like surgery
Ex vivo quantification of the time course of contractile loading of the porcine lens capsule after cataract-like surgery

Pedrigi RM, Dziezyc J, Kalodimos HA, Humphrey JD. Experimental Eye Research (2009).

PMID: 19638277


Image: Altered mechanical behavior and properties of the human anterior lens capsule after cataract surgery
Altered mechanical behavior and properties of the human anterior lens capsule after cataract surgery

Pedrigi RM, Dziezyc J, Humphrey JD. Experimental Eye Research (2009).

PMID: 19523944


2007

Image: Regional mechanical properties and stress analysis of the human anterior lens capsule
Regional mechanical properties and stress analysis of the human anterior lens capsule

Pedrigi RM, David G, Dziezyc J, Humphrey JD. Vision Research (2007).

PMID: 17467027


Image: Altered multiaxial mechanical properties of the porcine anterior lens capsule cultured in high glucose
Altered multiaxial mechanical properties of the porcine anterior lens capsule cultured in high glucose

Pedrigi RM, Staff E, David G, Glenn S, Humphrey JD. Journal of Biomechanical Engineering (2007).

PMID: 17227107


Image: Regional multiaxial mechanical properties of the porcine anterior lens capsule
Regional multiaxial mechanical properties of the porcine anterior lens capsule

David G, Pedrigi RM, Heistand MR, Humphrey JD. Journal of Biomechanical Engineering (2007).

PMID: 17227103


2006

Image: Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis
Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis

Heistand MR, Pedrigi RM, Dziezyc J, Humphrey JD. Journal of Biomechanical Engineering (2006).

PMID: 16024027


2005

Image: Multiaxial mechanical behavior of the porcine anterior lens capsule
Multiaxial mechanical behavior of the porcine anterior lens capsule

Heistand MR, Pedrigi RM, Delange SL, Dziezyc J, Humphrey JD. Biomechanics and Modeling in Mechanobiology (2005).

PMID: 15973538